|
KMID : 0882420130840030446
|
|
Korean Journal of Medicine
2013 Volume.84 No. 3 p.446 ~ p.451
|
|
|
Gefitinib Treatment for Pulmonary Sarcomatoid Carcinoma Driven by an EGFR Mutation: Two Cases
|
|
Kim Ji-Yeon
Lim Yoo-Joo
Lee Eun-Young
Kim Mi-So
Lee Dae-Won
Kim Tae-Min
Lee Se-Hoon
|
|
|
Abstract
|
|
|
|
Sarcomatoid carcinoma of the lung is defined as a group of poorly differentiated non-small cell carcinomas that contain a component of sarcoma or a sarcoma-like element. Most sarcomatoid carcinomas are known to have a poor prognosis. We describe a 45-year-old female never smoker and 49-year-old female never smoker with sarcomatoid carcinomas of the lung that expressed a specific EGFR mutation: microdeletion of exon 19. Their cancers progressed rapidly, despite appropriate conventional chemotherapy. After they took the EGFR-targeted agent gefitinib, there was a dramatic reduction in tumor size. Sarcomatoid carcinoma of the lung is a rare cancer whose pathogenesis is not well understood. According to these cases, the EGFR mutation could be a driver mutation and the potential therapeutic target of EGFR-targeted agents for sarcomatoid carcinoma in lung cancer patients, especially never smokers.
|
|
|
KEYWORD
|
|
|
Spindle cell carcinoma, Lung neoplasms, EGFR genes, Gefitinib
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
  
|